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From2010-11-03
To2010-11-06
Course

The course will be articulated in plenary lessons and workshops in smaller groups with practical examples. The plenary lectures of the course will be given by some of the most distinguished basic scientists in the field of mitochondrial  biology and cancer research. 

The course will be a groundbreaking event for discussing the metabolic changes in cancer cells and their clinical implications in current and future therapeutic approaches-engineering, with direct application to the analysis of biological data.

 

VenueBologna (Italy) - EuroMediterranean University Centre of Ronzano
Directors

G. Lenaz (Bologna, Italy)

G. Romeo (Bologna, Italy)

M. Rugolo ( Bologna, Italy)

Speakers

L. Alberghina (Milan, Italy)

M. Attimonelli (Bari, Italy)

M. Corral-Debrinski (Paris, France)

J. Cuezva (Madrid, Spain)

M.F. Di Renzo (Torino, Italy)

A.J. Enriquez (Zaragoza, Spain)

M. N. Gadaleta (Bari, Italy)

G. Gasparre (Bologna, Italy)

C. Giorgi (Ferrara, Italy)

E. Gottlieb (Glasgow, UK)

G. Lenaz (Bologna, Italy)

M. Giorgio (Milan, Italy)

G. Romeo (Bologna, Italy)

R. Rossignol (Bordeaux, France)

M. Rugolo (Bologna, Italy)

H. Simonnet (Lyon, France)

K. Singh (Buffalo, USA).

Programme
Wednesday, November 3rd

Morning Session: Bioenergetics and metabolism of cancer cells

08:30    Course Registration
09:00    J. Cuezva         The Bioenergetics signature of Cancer
09:45    R. Rossignol        From bioenergetics to the metabolic regulation of carcinogenesis
10:30     Coffee break
11:00    E. Gottlieb        Mitochondrial tumor suppressors: A genetic and biochemical link between                 

metabolism and cancer
11:45     H. Simonnet        Energy metabolism in proliferation and high nutrient demand
12:30     Poster Viewing 
13:00    Lunch break       
                                                  
Afternoon Session

14:30    Concurrent Workshops
15:30    Coffee break
16:00    Concurrent Workshops

Thursday, November 4th
Morning Session: Impact of mitochondria and mitochondrial genes dysfunction on cancer cells

09:00    E. Gottlieb     Metabolic sensors in cancer: from oxygen to amino acid sensing
09:45    G. Gasparre    mtDNA mutations in the metabolic adaptation of cancer cells: learning from oncocytic tumors

10:30     Coffee break

11:00    A. J. Enriquez    Respiratory chain defects and cancer development       
11:45     K. Singh    Epigenetic and Genetic Changes Induced by Mitochondrial Dysfunction and its role
Tumorigenesis
12:30     Poster Viewing 

13:00    Lunch break       

Afternoon Session
14:30    Concurrent Workshops
15:30    Coffee break
16:00    Concurrent Workshops

Friday, November 5th  –
Morning Session: Mitochondria-related molecular pathways in cancer

09:00 M. Giorgio    Mechanism of mitochondrial ROS production, signalling for cell
death and proliferation, side effects associated to mutagenesis and transformation
09:45 M.F. Di Renzo    Cells lacking fumarase are protected from apoptosis through a HIF independent,  AMPK dependent
mechanism
10:30     Coffee break
11:00    C. Giorgi    ER-mitochondria crosstalk in the control of cell fate
11:45     L. Alberghina     Ras and mitochondria in cancer cells 
12:30     Poster Viewing 
13:00    Lunch break       

Afternoon Session
14:30    Concurrent Workshops
15:30    Coffee break
16:00    Concurrent Workshops
17:00     Best Posters Ceremony

Saturday, November 6th 
Morning Session: Mitochondria-related aspects of cancer research

09:00    M.N. Gadaleta           Damage to mitochondrial DNA in aging and age-related diseases
09:45    M. Corral-Debrinski:     Inducing heteroplasmy of mtDNA mutations to generate experimental models of mitochondrial
diseases. Cellular adaptations to OXPHOS defects in cancer
10:30     Coffee break

11.00      M. Attimonelli        Bioinformatic approaches to study mtDNA variability in cancer
11:45    Course Director        Conclusions

12:30     Lunch Break
13:00     Departure
European School of Genetic Medicine