European School of Gennetic Medicine

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From	2010-11-03
To	2010-11-06
Course	The course will be articulated in plenary lessons and workshops in smaller groups with practical examples. The plenary lectures of the course will be given by some of the most distinguished basic scientists in the field of mitochondrial biology and cancer research. The course will be a groundbreaking event for discussing the metabolic changes in cancer cells and their clinical implications in current and future therapeutic approaches-engineering, with direct application to the analysis of biological data.
Venue	Bologna (Italy) - EuroMediterranean University Centre of Ronzano
Directors	G. Lenaz (Bologna, Italy) G. Romeo (Bologna, Italy) M. Rugolo ( Bologna, Italy)ï»¿
Speakers	L. Alberghina (Milan, Italy) M. Attimonelli (Bari, Italy) M. Corral-Debrinski (Paris, France) J. Cuezva (Madrid, Spain) M.F. Di Renzo (Torino, Italy) A.J. Enriquez (Zaragoza, Spain) M. N. Gadaleta (Bari, Italy) G. Gasparre (Bologna, Italy) C. Giorgi (Ferrara, Italy) E. Gottlieb (Glasgow, UK) G. Lenaz (Bologna, Italy) M. Giorgio (Milan, Italy) G. Romeo (Bologna, Italy) R. Rossignol (Bordeaux, France) M. Rugolo (Bologna, Italy) H. Simonnet (Lyon, France) K. Singh (Buffalo, USA).
Programme	Wednesday, November 3rd Morning Session: Bioenergetics and metabolism of cancer cells 08:30 Course Registration 09:00 J. Cuezva The Bioenergetics signature of Cancer 09:45 R. Rossignol From bioenergetics to the metabolic regulation of carcinogenesis 10:30 Coffee break 11:00 E. Gottlieb Mitochondrial tumor suppressors: A genetic and biochemical link between metabolism and cancer 11:45 H. Simonnet Energy metabolism in proliferation and high nutrient demand 12:30 Poster Viewing 13:00 Lunch break Afternoon Session 14:30 Concurrent Workshops 15:30 Coffee break 16:00 Concurrent Workshops Thursday, November 4th Morning Session: Impact of mitochondria and mitochondrial genes dysfunction on cancer cells 09:00 E. Gottlieb Metabolic sensors in cancer: from oxygen to amino acid sensing 09:45 G. Gasparre mtDNA mutations in the metabolic adaptation of cancer cells: learning from oncocytic tumors 10:30 Coffee break 11:00 A. J. Enriquez Respiratory chain defects and cancer development 11:45 K. Singh Epigenetic and Genetic Changes Induced by Mitochondrial Dysfunction and its role Tumorigenesis 12:30 Poster Viewing 13:00 Lunch break Afternoon Session 14:30 Concurrent Workshops 15:30 Coffee break 16:00 Concurrent Workshops Friday, November 5th – Morning Session: Mitochondria-related molecular pathways in cancer 09:00 M. Giorgio Mechanism of mitochondrial ROS production, signalling for cell death and proliferation, side effects associated to mutagenesis and transformation 09:45 M.F. Di Renzo Cells lacking fumarase are protected from apoptosis through a HIF independent, AMPK dependent mechanism 10:30 Coffee break 11:00 C. Giorgi ER-mitochondria crosstalk in the control of cell fate 11:45 L. Alberghina Ras and mitochondria in cancer cells 12:30 Poster Viewing 13:00 Lunch break Afternoon Session 14:30 Concurrent Workshops 15:30 Coffee break 16:00 Concurrent Workshops 17:00 Best Posters Ceremony Saturday, November 6th Morning Session: Mitochondria-related aspects of cancer research 09:00 M.N. Gadaleta Damage to mitochondrial DNA in aging and age-related diseases 09:45 M. Corral-Debrinski: Inducing heteroplasmy of mtDNA mutations to generate experimental models of mitochondrial diseases. Cellular adaptations to OXPHOS defects in cancer 10:30 Coffee break 11.00 M. Attimonelli Bioinformatic approaches to study mtDNA variability in cancer 11:45 Course Director Conclusions 12:30 Lunch Break 13:00 Departure