Consanguinity, that is the practice to get married between closely related individuals, is still a common habit in many regions of the world.
Although the worldwide prevalence of consanguineous unions seems to be declining, it is estimated that a 10.4% of the 6.7 billion global population is related as second cousins or closer.
This tendency remains particularly strong in those communities in which social and cultural tradition encourages close-kin marriages.
Within genetics, contemporary attention on consanguinity continues to be largely focused on rare autosomal recessive diseases. However, from an overall health perspective, consanguinity is a much wider and more complex topic involving major social, economic, and demographic influences.
The main aim of the course is to enhance sharing of knowledge and promote research on the molecular and statistical genetics aspects of consanguinity.
Workshops will include:
• Basic data handling and analysis using PLINK
• An introduction to ‘R’ for genetic analysis
• Estimating individual genome-wide homozygosity-by-descent using FEstim
• GWA analysis in genetically isolated populations using the GenABEL suite
• Homozygosity mapping using NGS alignment data.