Course in Mitochondrial Metabolism and Cancer

Registration fee: 400 euro + VAT 20% = 480 euro. The fee includes tuition, course material, lunch, coffee break and shuttle bus from Porta San Mamolo (meeting point) to the course venue and back. For info about accommodation, local transportation and other details please contact serena.paterlini@eurogene.org
For info about logistic details and accommodation please visit the following section: ACCOMMODATION INFO

Abstracts: Course Participants are invited to submit a poster concerning their research activity. Please send an abstract to: serena.paterlini@eurogene.org.

Course in Mitochondrial Metabolism and Cancer
EuroMediterranean University Centre of Ronzano
Bologna (Italy), November 3-6, 2010

DIRECTORS: G. Lenaz (Bologna, Italy), G. Romeo (Bologna, Italy), M. Rugolo ( Bologna, Italy)

SPEAKERS:

COURSE PROGRAM

Wednesday, November 3rd
Morning Session: Bioenergetics and metabolism of cancer cells

8:30 : Course Registration

9:00: J. Cuezva: The Bioenergetics signature of Cancer

9:30:R. Rossignol: From bioenergetics to the metabolic regulation of carcinogenesis

10:30: Coffee break

11:00: E. Gottlieb: Mitochondrial tumor suppressors: A genetic and biochemical link between metabolism and cancer

11:45: H. Simonnet: Energy metabolism in proliferation and high nutrient demand

12:30: Poster viewing and lunch break

Afternoon session:

14:00 -17:00: Concurrent workshops consisting in interactive discussions between one or more Faculty with groups of 20-25 students on the topics of the morning (30 minutes coffee break at 16:00)

Thurdsday, November 4th

Morning session: Impact of mitochondria and mitochondrial genes dysfunction on cancer cells

9:00: E. Gottlieb: Metabolic sensors in cancer: from oxygen to amino acid sensing

9:45: G. Gasparre: mtDNA mutations in the metabolic adaptation of cancer cells: learning from oncocytic tumors

10:30: Coffee break

11:00: A. J. Enriquez: Respiratory chain defects and cancer development

11:45: K. Singh : Epigenetic and Genetic Changes Induced by Mitochondrial Dysfunction and its role Tumorigenesis

12:30: Poster viewing and lunch break

13:00: Lunch break

Afternoon session:

14:00 -17:00: Concurrent workshops consisting in interactive discussions between one or more Faculty with groups of 20-25 students on the topics of the morning (30 minutes coffee break at 16:00)

Friday, November 5th

Morning session:  Mitochondria related molecular pathways in cancer

9:00: M. Giorgio, Mechanism of mitochondrial ROS production, signalling for cell death and proliferation, side effects associated to mutagenesis and transformation

9:45:M.F. Di Renzo: Cells lacking fumarase are protected from apoptosis through a HIF independent, AMPK dependent mechanism

10:30: Coffee break

11:00: C. Giorgi: ER-mitochondria crosstalk in the control of cell fate

11:45: L. Alberghina : Ras and mitochondria in cancer cells 

12:30: Poster viewing and lunch break

13:00: Lunch Break

Afternoon session:

14:30 -17:00: Concurrent workshops consisting in interactive discussions between one or more Faculty with groups of 20-25 students on the topics of the morning (30 minutes coffee break at 16:00)

17:00: Social drink for  Best Posters Ceremony

Saturday, November 6th

Morning session: Mitochondria related aspects of cancer research

9.00:  M. N. Gadaleta: Damage to mitochondrial DNA in aging and age-related diseases

9.45: M. Corral-Debrinski: Inducing heteroplasmy of mtDNA mutations to generate experimental models of mitochondrial diseases. Cellular adaptations to OXPHOS defects in cancer

10:30: Coffee break

11:00: M. Attimonelli: Bioinformatic approaches to study mtDNA variability in cancer

11:45: K. Singh: Conclusions

12.30:Lunch Break
13:00: Departure

All the participants will be encouraged to present a poster illustrating their current research activities. On Thursday 22nd, at the end of the workshop session, there will be spoken presentations of the best selected posters. The selection, based on the scientific content, will be made by the Faculty during the course.