From | 2011-10-25 |
To | 2011-10-28 |
Course | Cytogenetics witnessed, in recent years, a series of technological innovation that forced the field to completely and repeatedly renew its approach and vision of chromosomal imbalances and copy number variation in the population, in cancer and in evolution. Molecular cytogenetics, microarray-CGH, and massive sequencing technologies are the most relevant techniques that trigged these changes. The Course is designed to give a broad overview of these technologies and to discuss with attendants the way they integrate each other in a modern genetic/cytogenetic laboratory. |
Venue | EuroMediterranean University Center of Bologna |
Directors | M. Rocchi (Bari, Italy) F. Mitelman (Lund, Sweden) B. Young (London, UK) |
Speakers | p>S. Daoud (Amsterdam, The Netherlands)
M. Iascone (Bergamo, Italy) F. Mitelman (Lund, Sweden) M. Rocchi (Bari, Italy) J. Vermeesch (Leuven,Belgium) B. Ylstra (Amsterdam, The Netherlands) F. Speleman (Ghent, Belgium) O. Zuffardi (Pavia, Italy) B. Young (London, UK) |
Programme | October 25th Tue
Morning Session
8.30-9.30 Cytogenetic evolution M. Rocchi 9.30-10.30 Cancer cytogenetics 1 F. Mitelman 10.30-11.00 Coffee break 11.00-12.00 Cancer cytogenetics 2 F. Mitelman 12.00-13.00 Microarrays: general introduction B.Ylstra 13.00 Lunch
Afternoon Session
14.30-15.30 Parallel sequencing: general introduction J. Veermesch 15.30- 18.00 Concurrent Workshops 1 Workhop: Array CGH platforms compared B. Ylstra 16.30-17.00 Break 2 Workshop: Cytogenetics and parallel sequencing practical aspects (I) M. Iascone
October 26 Wed
Morning Session
8.30-9.30 Evolution of cytogenetics as a discipline O. Zuffardi 9.30-10.30 Copy Number Variation in the human population J. Veermesch 10.30-11.00 Coffee break 11.00-12.00 Human genome plasticity M. Rocchi 12.00-13.00 miRNAs and disease F. Speleman 13.00 Lunch
Afternoon Session
14.30-15.30 Long non coding RNAs: the important unknowns F. Speleman 15.30-18.00 Concurrent Workshops 1 Workshop: Resources for molecular cytogenetics M. Rocchi 16.30-17.00 Break 2 Workshop: MicroRNAs and long non coding RNAs: practical aspect F.Speleman
October 27 Thu
Morning Session 8.30-9.30 Expression profiling by microarray B. Young 9.30-10.30 Genome wide CNV and SNP detection in single cells J. Veermesch 10.30-11.00 Coffee break 11.00-12.00 The application of SNP arrays to the cancer genome B. Young 12.00-13.00 Inherited causative imbalances: the two hits hypothesis applies not only to tumors O. Zuffardi 13.00 Lunch
Afternoon Session
14.30-15.30 Technology advancement from microarrays to therapy B. Ylstra 15.30-18.00 Concurrent Workshops 1 Workshop Cytogenetics and parallele sequencing: practical aspect (II) M. Iascone 16.30-17.00 Break t.b.d B. Young 2 Workshop S. Daoud: Short Read Sequence data, processing, annotation and data exploration.
October 28 Fri Workshop organized in the framework of the European Project Cherish (Improving Diagnoses of Mental Retardation in Children in Eastern Europe and Central Asia through Genetic Characterisation and Bioinformatics/Statistics Mental retardation).
8.30 Welcome and registration 8.45-9.30: G. Romeo, E. Bonora, C. Graziano: Introduction of the CHERISH project: data, goals, hope 9.30-10.15: O. Zuffardi “Next generation sequencing: the great expectation in de novo and inherited mental retardation 10.15-11.00: J. Veermesch "About inherited causal and de novo benign copy number variants" 11.00-11.30 Coffee-break 11.30-12.15 S. Daude: Next Gen Sequencing, current applications in cancer genetics 12.15-13.00 Q&A and open discussion |