From | 2009-04-18 |
To | 2009-04-22 |
Course | Mitochondrial Medicine is a relevant, steadily expanding area of Genetic Medicine. The complexity of the metabolic pathways associated with mitochondrial energy homeostasis and the peculiar genetics dictating mitochondrial inheritance in humans, account for the extraordinarily wide spectrum of clinical presentations and genetic abnormalities associated with mitochondrial disorders. This Course on Mitochondrial Medicine intends to offer to European biochemists and biologists, geneticists and physicians the basic and clinically oriented information on this frontline scientific field, through an articulate program organized in morning plenary lectures and afternoon workshops in smaller groups. The course will end with plenary lectures dedicated to late Prof. Giuseppe Attardi (1923-2008), one of the leading scientists in mitochondrial biology. Plenary lectures and workshops will be given by some of the most distinguished basic scientists and medical researchers in the field of mitochondrial pathophysiology and medicine. |
Venue | |
Directors | M. Zeviani(Milan, Italy),V. Carelli (Bologna, Italy), A. Munnich (Paris, France) |
Speakers | P. Bernardi (Padua, Italy), S. Calvo( Cambridge, USA), P. Cantatore (Bari, Italy), V. Carelli (Bologna, Italy), P. Chinnery (New Castle, UK), A. Chomyn (Pasadena, USA), A. J. Enriquez (Zaragoza, Spain), I. Holt (Cambridge, UK), H. T. Jacobs (Tampere, Finland), G. Lenaz (Bologna, Italy), A. Martinuzzi (Conegliano, Italy), J. Montoya ( Zaragoza, Spain), A. Munnich (Paris, France),G. Romeo (Bologna, Italy), A. Rotig (Paris, France), E. Rugarli (Milan, Italy), G. Schatz (Basel, Switzerland), L. Scorrano(Geneve,Switzerland), V. Tiranti(Milan, Italy), A. Torroni(Pavia, Italy), A. Trifunovic (Stockholm, Sweden), G. Villani(Bari, Italy), M. Zeviani(Milan, Italy) D. Wallace (Irvine, USA), J. Walker (Cambridge, UK), A. Suomalainen Wartiovaara(Helsinki, Finland) |
Programme | April 18: Mitochondrial biology - Morning plenary lectures
Morning
8.00- Course Registration
8.15- G. Lenaz Historical perspective: from bioenergetics to mitochondrial medicine.
8.35 Paolo Bernardi, Bioenergetics of OXPHOS, ROS production and mitochondrial apoptosis
9.15 José-Antonio Enriquez, The mitochondrial respiratory chain: structure, function and plasticity
10.00 Coffee break
10.30 Ian Holt, The structure of mtDNA: Gene organization, replication and expression
11.15 Luca Scorrano, The mitochondrial network: fusion and fission in biogenesis and disease
12.00 Sarah Calvo, Dissecting the mitochondrial proteome in health and disease
12.45 Questions session
13.15 Lunch
Afternoon
14.40 - Concurrent Workshops
Paolo Bernardi Bioenergetics in practice
Ian Holt Analysis of mtDNA replication in practice
16.15 Coffee break 16.30 Concurrent Workshops
Antonio-José Enriquez Analysis of the respiratory chain in practice
Sarah Calvo Biocomputational analysis in practice
Luca Scorrano Mitochondrial dynamics in practice
April 19: Mitochondrial diseases 1 - Morning plenary lectures
Morning
9:00 Antonio Torroni, Genetic variation of mtDNA in human population genetics, health and disease
9.45 Julio Montoya, mtDNA mutations in mitochondrial disorders
10. 30 Coffee break
11.00 Valeria Tiranti, Nuclear disease genes in mitochondrial disorders
11.45 Agnes Rotig, Disorders of respiratory chain cofactors
12.35 Questions session
13.00 Lunch
Afternoon
14.40 - Workshop
Anne Chomyn Rho Zero Cells and Cybrids: Theory, Practice, and Power.
16.15 Coffee break
16.30 Concurrent Workshops
Agnes Rotig Linkage analysis and other gene finding strategies
Valeria Tiranti From gene finding to protein understanding
April 20: Mitochondrial diseases 2- Morning plenary lectures
Morning
9. 00 Anu Suomalainen Wartiovaara, Disorders of intergenomic communication
9.45 Valerio Carelli, Mitochondrial biogenesis and compensatory strategies in mitochondrial diseases
10. 30 Coffee break
11.00 Arnold Munnich, Clinical approach to mitochondrial disease: genetic counselling and its social implications
11.45 Patrick Chinnery, Therapy of Mitochondrial Disorders
12.35 Questions session
13.00 Lunch
Afternoon
14.40 - Concurrent Workshops
Aleksandra Trifunovic Animal and yeast models in mitochondrial medicine
Valerio Carelli Genetic counseling in mitochondrial medicine
16.15 Coffee break
16.30 Concurrent Workshops
Patrick Chinnery Clinical assessment in Mitochondrial Medicine
Anu Suomalainen Waartiovara Epidemiology and ethnic variation in mitochondrial disorders
Ileana Ferrero Manipulating yeast: a fundamental tool to understand mitochondrial disease
April 21: Mitochondrial dysfunction in neurodegeneration, ageing and cancer
Morning
9.00 Alexandra Trifunovic - Mitochondrial Ageing
9.45 Giovanni Romeo - Mitochondria and Cancer
10. 30 Coffee break
11. 00 Elena Rugarli - Mitochondrial Neurodegeneration
11.45 Douglas C. Wallace - The past, present and future of Mitochondrial Medicine
12.35 Questions session
13.00 Lunch
Free afternoon
April 22 - Attardi’s day in Padua
Organizers: M. Zeviani (Milan, Italy), P. Bernardi (Padua, Italy)
10.15 Welcome and opening ceremony 10.30 A.Chomyn Per aspera ad astra
Morning Session Chairpersons: G. Lenaz, P. Bernardi
10.45 J. Walker Key note lecture - Mitochondrial power: energy and structure 11:30 J. Montoya Mitochondrial DNA structure and function: unraveling the magic circle 12.00 P. Cantatore Mitochondrial DNA transcription and its regulation in animal cells 12.30 I. Holt Three revolutions of the magic circle 13:00
Lunch Break
Afternoon Session Chairpersons: H. T. Jacobs, M. Zeviani
14.00 A. Martinuzzi Cybrids: a workhorse for the dissection of mitochondrial physiopathology 14.25 G. Villani Control of mitochondrial OXPHOS: not "just" a question of flux 14.50 A. J. Enriquez ROS signaling and OXPHOS 15.15 D.C. Wallace Attardi`s Lecture: Why we still have a maternally inherited mitochondrial DNA - Insights into degenerative diseases, aging and cancer
16:00 Coffee break
Chairpersons: A. Chomyn, J. Montoya
16.20 V. Carelli t.b.d 16.45 P. Bernardi Mitochondrial diseases and the permeability transition pore: a new threshold? 17.10 A. Trifunovic Are mtDNA mutations driving force of aging?" 17.35 M. Zeviani The rise and fall of respiratory domains: assembly defects in mitochondrial disorders 18:00 G. Schatz Closing lecture: Critical moments in mitochondrial research - and Giuseppe Attardi
18:45 H.T. Jacobs Concluding remarks 19:00 End of symposium |