Translational aspects of proteolysis in neurodegenerative diseases

1- 2 July 2010, Maastricht, The Netherlands
School of Governance, Maastricht, The Netherlands

Organizers: F.W. van Leeuwen and N. Kholod

Protein quality control systems are essential for neuronal function. In neurodegenerative diseases these systems are partial dysfunctional.
In the present satellite failures of the main protein degradation systems will be discussed, their downstream consequences for synaptic plasticity and strategies for therapy. Translational aspects for combating these diseases will be presented.

Thursday July 1 17:00

Opening
Prof. Dr. M. Paul, Dean of the Faculty of Health, Medicine and Life Sciences (FHML), University Maastricht

Opening lecture
A. Ciechanover* - Nobel Laureate 2004 (Technion-Israel Institute of Technology, Haifa, Israel)
The ubiquitin system: past history and future challenges
* ENZO LIFE SCIENCES (UK) LTD lecture

Welcome reception

Friday July 2 09:00

M. Glatzel (University Medical Center Hamburg-Eppendorf, Hamburg, Germany)
Crosstalk between unfolded protein response, ubiquitin-proteasome system and autophagy in vivo

J.J. Lucas (Centro de Biologia Molecular "Severo Ochoa", CSIC/UAM. Madrid, Spain)
The ubiquitin-proteasome system in Huntington’s disease

H. Paulson (University of Michigan, Ann Arbor, USA)
Protein quality control in polyglutamine neurodegenerative diseases: insights leading toward therapies

F.W. van Leeuwen (Maastricht University, Maastricht, The Netherlands)
Misframed ubiquitin in tauopathies and polyglutamine diseases; interactions with Aβ plaque formation and intranuclear inclusions
unch break

D.C. Rubinsztein (University of Cambridge, Cambridge, UK)
Autophagy, aggregates and neurodegeneration

K. Kosik** (University of California Santa Barbara, USA)
Tau degradation pathways and opportunities for intervention in Alzheimer's disease
** ISAO lecture

S. M. Wilson (University of Alabama at Birmingham, Birmingham, USA)
Synaptic dysfunction and the ubiquitin-proteasome system